Study No. 21

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The property is also significant under Criterion C because it embodies the distinctive characteristics of residential architecture associated with the Case Study House Program. Therefore, the property qualifies for listing under Criteria A and C at the local level of significance.

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Ware , Bruce D. Gelb , and Mark W. Abstract Download PDF This review provides an updated summary of the state of our knowledge of the genetic contributions to the pathogenesis of congenital heart disease.

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Since , when the initial American Heart Association scientific statement on the genetic basis of congenital heart disease was published, new genomic techniques have become widely available that have dramatically changed our understanding of the causes of congenital heart disease and, clinically, have allowed more accurate definition of the pathogeneses of congenital heart disease in patients of all ages and even prenatally.

Information is presented on new molecular testing techniques and their application to congenital heart disease, both isolated and associated with other congenital anomalies or syndromes. Insights into new research with congenital heart disease models, including genetically manipulated animals such as mice, chicks, and zebrafish, as well as human induced pluripotent stem cell—based approaches are provided to allow an understanding of how future research breakthroughs for congenital heart disease are likely to happen.

It is anticipated that this review will provide a large range of health care—related personnel, including pediatric cardiologists, pediatricians, adult cardiologists, thoracic surgeons, obstetricians, geneticists, genetic counselors, and other related clinicians, timely information on the genetic aspects of congenital heart disease. The objective is to provide a comprehensive basis for interdisciplinary care for those with congenital heart disease.

Anderson Jennifer L. Dearborn Erin P. Lichtenstein Volume Issue 11 Circulation 9 August Chung Vidu Garg Ronald V. Lacro Amy L. Priest William T. Pu Amy Roberts Stephanie M. Ware Bruce D. Gelb Mark W. Russell Volume Issue 21 Circulation 27 September